Slayers originally began as a series of 50 light novels written by Hajime Kanzaka. It also has several mangas, anime series, OVAs, and movies. The main character of Slayers is Lina Inverse, a powerful young sorceress who is known for causing mayhem and destruction, and is very sensitive about her small breast size.
Standing in the Battledome:
Slayers is a very powerful universe, it spans at least a multiverse (possibly a megaverse, the anime version of Lost Universe is also part of the Slayers continuity), which was created and is ruled over by the Lord of Nightmares, a possible omnipotent being who usually takes the form of a blond - haired woman. She is known as the Sea of Chaos, and all of the universes/multiverses/etc. in the Slayers continuity are just part of her body that she created for fun. A spell drawing from her power, the Giga Slave, can destroy an entire universe if miscast. There are also the Mazoku, non-corporeal spirit beings that can only be killed by astral attacks, and many have powerful reality-warping abilities.
The Slayersverse is inhabited with all sorts of beings, including your generic Tolkienesque fantasy races and stranger things. It is known for its comedic aspects as well as its power.